National Day of Prayer – May 5 The National Day of Prayer is observed annually on the first Thursday in May. This day observance, designated by the United States Congress, asks people to turn to God in prayer and meditation. The theme for the 2022 National Day of Prayer is a call to praise in prayer: ‘EXALT THE LORD, WHO HAS ESTABLISHED US’ based on Colossians 2:6-7 Mary Queen of Peace Pray for Us!